Astros vs. Blue Jays Prediction, Odds, Picks - April 22

Data Skrive

Isaac Paredes and the Houston Astros will take on Vladimir Guerrero Jr. and the Toronto Blue Jays at Daikin Park in the first of a three-game series, on Tuesday at 8:10 p.m. ET. The Blue Jays are listed as -104 moneyline underdogs for this matchup against the favorite Astros (-116). Toronto is favored on the run line (-1.5). An 8.5-run over/under has been set in this matchup.

Take a look at everything you need to know from a betting perspective on the Astros-Blue Jays game, regarding the run line, moneyline and total, plus expert picks.

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Check out the best moments between the Seattle Mariners and Toronto Blue Jays

Astros vs. Blue Jays Game Information & Odds

When: Tuesday, April 22, 2025 at 8:10 p.m. ET
Where: Daikin Park in Houston, Texas
How to watch on TV: SCHN and SN1

Favorite Favorite Moneyline Underdog Moneyline Total Over Total Odds Under Total Odds Run Line Favorite Run Line Odds Underdog Run Line Odds Astros -116 -104 8.5 -109 -111 -1.5 -189 +155

Astros vs. Blue Jays Prediction

Score Prediction: Astros 5, Blue Jays 4
Total Prediction: Over 8.5 runs
Win Probabilities: Astros 55%, Blue Jays 45%

Astros vs. Blue Jays Betting Insights

The Astros have entered the game as favorites 13 times this season and won six, or 46.2%, of those games.
Houston has a record of 6-5 in games when oddsmakers favor them by at least -116 on the moneyline.
The moneyline for this contest implies a 53.7% chance of a victory for the Astros.
The Blue Jays have come away with seven wins in the 15 contests they have been listed as the underdogs in this season.
This year, Toronto has won five of 12 games when listed as at least -104 or worse on the moneyline.
Oddsmakers have implied with the moneyline set for this matchup that the Blue Jays have a 51% chance of pulling out a win.

Astros Recent Betting Performance

The Astros were the moneyline favorite for eight of their last 10 games, and they went 4-4 in those matchups.
Over their last 10 matchups (all 10 of them had set totals), the Astros and their opponents combined to hit the over five times.
The Astros’ record against the spread is 6-4-0 over their past 10 games.

Astros Recent Stats

Stat Avg/Total Record 5-5 Runs Per Game 4.5 HR 10 ERA 3.82 K/9 7.6

Astros Player Insights

Jeremy Pena has collected a team-high three home runs.
Of all hitters in baseball, Pena’s home run total places him 73rd, and his RBI tally puts him 157th.
Pena brings a hitting streak of 11 games into this game. In his last 10 outings he is hitting .297 with three doubles, a home run, four walks and five RBI.
Jose Carlos Altuve has hit three home runs to lead his team.
Altuve ranks 73rd in home runs and 157th in RBI among all hitters in baseball.
Paredes leads the Astros with three home runs and 11 runs batted in.
Jake Meyers‘ .305 batting average leads his team.

Blue Jays Recent Betting Performance

In nine games over the last 10 matchups when set as underdogs by oddsmakers, the Blue Jays had a record of 4-5.
When it comes to hitting the over, the Blue Jays and their opponents are 6-4-0 in their last 10 games with a total.
The Blue Jays have won seven of their last 10 games against the spread.

Blue Jays Recent Stats

Stat Avg/Total Record 5-5 Runs Per Game 3.9 HR 6 ERA 3.50 K/9 10.5

Blue Jays Player Insights

Bo Joseph Bichette has driven in the most runs for the Blue Jays with 13 runs batted in.
In all of the big leagues, Bichette ranks 269th in homers and 38th in RBI.
Bichette takes a hitting streak of five games into this matchup. During his last five outings he is hitting .364 with three doubles, a walk and three RBI.
Guerrero is hitting .305 with six doubles, a home run and 14 walks.
Among all major league hitters, Guerrero ranks 169th in home runs and 84th in RBI.
Andres Gimenez has three home runs, best in the lineup.
George Springer leads the team in batting average with a high-water mark of .344.

Check out the best moments between the Seattle Mariners and Toronto Blue Jays

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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