A three-game series between the Chicago Cubs (12-9) and the Arizona Diamondbacks (12-7) starts up on Friday afternoon. Arizona has strung along a five-game win streak. The Diamondbacks topped the Miami Marlins 6-4 yesterday. Meanwhile, the San Diego Padres beat the Cubs 4-2 on Wednesday.

First pitch is scheduled for 2:20 p.m. ET at Wrigley Field in Chicago. The Diamondbacks are the -112 money-line favorites (bet $112 to win $100) in the latest Diamondbacks vs. Cubs odds, while the Cubs are -104 underdogs (bet $104 to win $100). The over/under for total runs scored is 11.5 in the latest MLB odds. 

Before you make any Diamondbacks vs. Cubs picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 4 of the 2025 MLB season on an 8-3 run on top-rated money-line picks (+340). Anybody following could have seen strong returns!

The model has simulated Diamondbacks vs. Cubs 10,000 times and the results are in. We can tell you the model is going Under on the run total, and it also says one side of the money line has all the value!

Who wins Diamondbacks vs. Cubs, and which side of the money line has all the value? … Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 8-3 roll on top-rated MLB picks!