Guardians vs. Angels Prediction, Odds, Picks - April 5

Data Skrive

Jose Ramirez and Taylor Ward will be among the stars on display when the Cleveland Guardians face the Los Angeles Angels on Saturday at 9:38 p.m. ET, at Angel Stadium. The Angels have been listed as +123 moneyline underdogs in this matchup with the favorite Guardians (-146). Cleveland is the favorite on the run line (-1.5). The total is 8 runs for this matchup (with -102 odds to hit the over and -118 odds to go under).

Check out everything you need to know from a betting perspective on the Guardians-Angels game, regarding the run line, moneyline and total, plus expert picks.

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Check out the best moments between the Los Angeles Angels and the St. Louis Cardinals.

Guardians vs. Angels Game Information & Odds

When: Saturday, April 5, 2025 at 9:38 p.m. ET
Where: Angel Stadium in Anaheim, California
How to watch on TV: FDSW and CLEG

Favorite Favorite Moneyline Underdog Moneyline Total Over Total Odds Under Total Odds Run Line Favorite Run Line Odds Underdog Run Line Odds Guardians -146 +123 8 -102 -118 -1.5 +115 -136

Guardians vs. Angels Prediction

Score Prediction: Guardians 4, Angels 2
Total Prediction: Under 8 runs
Win Probabilities: Guardians 68%, Angels 32%

Guardians vs. Angels Betting Insights

The Guardians will play as the favorite for the first time this season.
Cleveland has not entered a game this season with shorter moneyline odds than -146.
The sportsbooks’ moneyline implies a 59.3% chance of a victory for the Guardians.
The Angels have been underdogs in three games this season and have come away with the win two times (66.7%) in those contests.
Los Angeles has played as an underdog of +123 or more just one time this year and came away with a win in that game.
Sportsbooks have implied with the moneyline set for this matchup that the Angels have a 44.8% chance of pulling out a win.

Guardians Player Insights

The Guardians’ best power option comes in the form of Kyle Manzardo and his two-homer seven-RBI season, both team highs.
In all of the majors, Manzardo is 27th in homers and 21st in RBI.
Steven Kwan is batting .348 to lead his team.
Kwan ranks 63rd in homers and 94th in RBI in the major leagues.
Kwan has two games in a row with at least one hit. In his last five games he is batting .316 with a home run, two walks and two RBI.
Carlos Santana is batting .261 with two doubles and two walks.
Ramirez has two doubles, a home run and a walk while hitting .294.

Angels Player Insights

Kyren Paris has a triple, a home run and two walks while batting .444.
Paris’ home run total puts him 63rd in the majors, and he ranks 94th in RBI.
Paris has collected a hit in four games in a row. In his last five games he is hitting .444 with a triple, a home run, two walks and three RBI.
Nolan Schanuel’s .292 batting average is a team-high mark.
Schanuel is currently 157th in home runs and 94th in RBI in the big leagues.
Mike Trout has put up a team-high five runs batted in.
Logan O’Hoppe leads the Angels with two long balls and runs batted in, driving in five.

Check out the best moments between the Los Angeles Angels and the St. Louis Cardinals.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Los Angeles Angels

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